Thesis anticancer agents

It also showed growth inhibitory effects in the range 1. In turn, members of four classes of plant-derived compounds are used widely as antitumor agents, namely, the bisindole vinca alkaloids, the camptothecins, the epipodophyllotoxins, and the taxanes [ 2 ].

Asiaticoside was found possessing prominent wound healing activity which may be associated with its effect on collagen synthesis.

Although less potent than cisplatin, the construct is equally toxic to both cell lines, thereby indicating that targeting the mitochondria provides a viable strategy for circumventing resistance to platinum drugs.

Human cancer cells are propagated within fibers that are implanted either subcutaneously s. Astralagus Hedysarum A polysaccharide from Astralagus hedysarum has shown anti tumor activity.

Synthetic strategies for the design of platinum anticancer drug candidates

Taraxacum Officinale Dandelions are common name of plants belong to genus Taraxacum. Andrographis Paniculata Phytochemical investigation of the ethanol extract of the aerial parts of Andographis paniculata has been reported the isolation of 14 compounds; a majority of them are flavonoids and labdane diterpenoids.

It was shown very recently by Shnyder and colleagues that like the parent compound, 4 is also potently cytotoxic for Thesis anticancer agents cell lines. Pericosine A was more cytotoxic than an analog, pericosine B, when evaluated in vitro against the P lymphocytic leukemia cell line ED50 0.

Taraxacum have a long history of use in several tribes and countries and also used to combat a wide variety of diseases Thesis anticancer agents cancer. As a result of these efforts, only two additional platinum-based drugs received FDA approval for the treatment of cancer.

In our experience, however, only a small percentage of compounds determined to be cytotoxic against human cancer cells ultimately prove to have in vivo activity on subsequent biological testing. Other tubeimosides like tubeimodes-I, tubeimoside-II and tubeimoside-II also exhibited promised cytotoxic activity which may be linked to the inhibition of DNA synthesis and may induce phenotypic reverse transformation of tumor cells [ 37 ].

Parkinson like symptoms can occur on oral ingestion of graviola [ 26 ]. In addition, there are several examples of promising natural product-derived antineoplastic agents currently in advanced clinical development or recently approved, not only from microbes e.

It was also observed that EGCG inhibit the growth of cancer cell lines like hepatocellular carcinoma through induction of cell cycle arrest [ 43 ]. Preliminary research showed that acetogenins block production of adenosine triphosphate, which inhibits the pump that removes cancer drugs from the cell, allowing chemotherapy to be more effective.

Consequently, the supply of a given precious natural product sample may be enhanced, and it may be possible to determine a preliminary notion of structure-activity relationships and of its potential mechanism of action.

Scutellaria barbata ethanol extract significantly reduced the growth of A cell, with an IC50 value of 0. In in vitrostudy the non-alkaloid fraction containing mainly nonpolar compounds showed the most significant inhibitory activity [ 17 ]. A variety of biophysical techniques such as thermal melting experiments, biosensor surface plasmon resonance, circular dichroism, fluorescence displacement assay and mass spectrometry were employed to evaluate the affinity of the compounds and their recognition properties.

This would then be tested against a number of human cancer cells, such as the U. Mice were injected subcutaneously with MCF-7 breast cancerous cells in the flank area and monitored for tumor growth. Although no clear structure-activity relationships could be delineated, the complexes exhibited activity on the same order of magnitude as that of the clinically established drug cisplatin.Appendix C.

Synthesis and Characterization of Several Novel Platinum Complexes Throughout the course of this thesis work, several platinum complexes were synthesized and characterized, but ultimately not fully pursued as potential anticancer agents.

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Liposomal Drug Delivery of Anticancer Agents Synthesis, Biophysical Characterization and Biological Studies of Enzyme Sensitive Phospholipid Prodrugs. contribution in the accomplishment of this thesis.

Prof. E. W. Neuse, my supervisor, for his extreme kindness, helpfulness and tireless guidance. Prof. Connie Medlen, Department of Pharmacology, University of Pretoria, and her research team members; Neil Margo and Suzaan Visser, for all the cell culture testing experiments.

SCHWEINFURTHINS AS NOVEL ANTICANCER AGENTS by Craig Heath Kuder UAn Abstract Of a thesis submitted in partial fulfillment of the requirements for the Doctor of. future. Chemotherapy, as well as surgery and radiation, is an important clinical method to successfully treat cancer.

Within the chemotherapeutic agents, natural products and chemicals derived from or related to natural products constitute an important part of the oncologist‟s armamentarium.

Thesis Submitted in Partial Fulfilment Of the Requirements for the Degree of [Name of program] [Name of University] [Last month of quarter you plan to graduate] 20XX. Natural Product as Anti-Cancer Agent 2 anti-cancer agents has been extensively discussed in academic resources.

There are many natural.

Thesis anticancer agents
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